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Chemical Structure : CR4056
Catalog No.: PC-35650Not For Human Use, Lab Use Only.
CR4056 (CR 4056, CR-4056) is a novel, orally active imidazoline-2 receptor (I2R) ligand with binding IC50 of 596 nM, also selectively inhibits the enzymatic activity of MAO-A with IC50 of 202.7 nM.
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CR4056 (CR 4056, CR-4056) is a novel, orally active imidazoline-2 receptor (I2R) ligand with binding IC50 of 596 nM, also selectively inhibits the enzymatic activity of MAO-A with IC50 of 202.7 nM; increases norepinephrine (NE) tissue levels both in the rat cerebral cortex and lumbar spinal cord, shows ED50 of 5.8 mg/kg in CFA rat model of inflammatory pain; shows high effectivity against bortezomib-induced painful neuropathy in rats.
Pain
Phase 2 Clinical
| M.Wt | 272.311 | |
| Formula | C17H12N4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ferrari F, et al. J Pain Res. 2011;4:111-25.
2. Thorn DA, et al. Br J Pharmacol. 2012 Jul;166(6):1936-45.
3. Meregalli C, et al. J Pain Res. 2012;5:151-67.
4. Lanza M, et al. Br J Pharmacol. 2014 Aug;171(15):3693-701.
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