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Chemical Structure : CRAC inhibitor 36
Catalog No.: PC-38654Not For Human Use, Lab Use Only.
CRAC inhibitor 36 is a novel potent, selective calcium release-activated calcium (CRAC) channels inhibitor with IC50 of 11 nM (IL-2 inhibition) and 243 nM (SOCE inhibition).
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CRAC inhibitor 36 is a novel potent, selective calcium release-activated calcium (CRAC) channels inhibitor with IC50 of 11 nM (IL-2 inhibition) and 243 nM (SOCE inhibition).
CRAC inhibitor 36 showed decent potency and selectivity and a remarkable pharmacokinetic profile, good target engagement as measured by levels of IL-2 and TNF-α.
| M.Wt | 421.404 | |
| Formula | C23H17F2N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Khedkar NR, et al. J Med Chem. 2021 Dec 9;64(23):17004-17030.
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