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Chemical Structure : CRD733
Catalog No.: PC-49573Not For Human Use, Lab Use Only.
CRD733 (ASP4901) is a potent, selective cGMP-specific PDE9 (phosphodiesterase 9) inhibitor.
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CRD733 (ASP4901) is a potent, selective cGMP-specific PDE9 (phosphodiesterase 9) inhibitor.
CRD-733 reverses TAC-induced left ventricular (LV) hypertrophy in vivo.
CRD-733 reverses TAC-induced left ventricular dysfunction in mice.
CRD-733 does not reverse TAC-induced left ventricular (LV) cardiac fibrosis, but attenuates fibrotic gene expression, increases plasma cGMP levels.
| M.Wt | 369.216 | |
| Formula | C15H10Cl2N2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Daniel A Richards, et al. Circ Heart Fail. 2021 Jan;14(1):e007300.
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