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Chemical Structure : CREB inhibitor 666-15
CAS No.: 1433286-70-4
Catalog No.: PC-38619Not For Human Use, Lab Use Only.
CREB inhibitor 666-15 is a potent and selective inhibitor of CREB-mediated gene transcription with IC50 of 81 nM, potently inhibits cancer cell growth without harming normal cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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CREB inhibitor 666-15 is a potent and selective inhibitor of CREB-mediated gene transcription with IC50 of 81 nM, potently inhibits cancer cell growth without harming normal cells.
CREB inhibitor 666-15 is highly seletive, shows very weak activity against NF-κB-mediated gene transcription with IC50 of >5 uM.
CREB inhibitor 666-15 decreases endogenous CREB target gene expression, shows significant inhibition of transcription of Nurr1/NR4A2 in HEK 293T cells at 50 nM.
CREB inhibitor 666-15 potently inhibits growth of MDA-MB-231 and MDA-MB-468 cells with GI50 in the midnanomolar concentration range (<100 nM).
CREB inhibitor 666-15 (10 mg/kg, i.p.) suppresses MDA-MB-468 tumor growth in vivo.
| M.Wt | 620.52 | |
| Formula | C33H31Cl2N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-(3-Aminopropoxy)-N-[2-[[3-[[(4-chloro-2-hydroxyphenyl)amino]carbonyl]-2-naphthalenyl]oxy]ethyl]-2-naphthalenecarboxamide hydrochloride |
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1. Fuchun Xie, et al. J Med Chem. 2015 Jun 25;58(12):5075-87.
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