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Chemical Structure : CS-0777
Catalog No.: PC-61014Not For Human Use, Lab Use Only.
CS-0777 is a potent, selective, orally active S1P receptor-1 (S1P1) agonist with EC50 of 1.1 nM, 320-fold selectivity over S1P3.
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CS-0777 is a potent, selective, orally active S1P receptor-1 (S1P1) agonist with EC50 of 1.1 nM, 320-fold selectivity over S1P3.
CS-0777 significantly decreases lymphocyte counts at doses of 0.1 and 1 mg/kg in rats, demonstrates potential benefits in the treatment of autoimmune diseases.
| M.Wt | 342.483 | |
| Formula | C21H30N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nishi T, et al. ACS Med Chem Lett. 2011 Mar 2;2(5):368-72.
2. Yonesu K, et al. J Biol Chem. 2011 Jul 15;286(28):24765-75.
3. Moberly JB, et al. J Neuroimmunol. 2012 May 15;246(1-2):100-7.
4. Inaba S, et al. Xenobiotica. 2015;45(12):1063-80.
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