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Chemical Structure : CSB-0914
Catalog No.: PC-21657Not For Human Use, Lab Use Only.
CSB-0914 is a small molecule NF-κB inhibitor that stably binds to NF-κB-p50 subunit, exhibits significant efficacy in reducing basophil activation assay induced by FcεRI receptors with IC50 of 98.4 nM.
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CSB-0914 is a small molecule NF-κB inhibitor that stably binds to NF-κB-p50 subunit, exhibits significant efficacy in reducing basophil activation assay induced by FcεRI receptors with IC50 of 98.4 nM.
CSB-0914 dose dependently reduces degranulation, effectively reduced the release of TNF-α and IL-2 in DNB-BSA stimulated IgE sensitized RBL-2H3 cells.
CSB-0914 inhibits anti-IgE-FcεRI-stimulated activated basophils with CD63 cell population with IC50 of 98.4 nM.
CSB-0914 inhibits neutrophil elastase activity and reduced neutrophil migration. inhibits phosphorylation of NF-κB and upregulated nrf-2 and HO-1 proteins.
| M.Wt | 346.39 | |
| Formula | C20H18N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mesfer Al Shahrani, et al. J Biomol Struct Dyn. 2023 Dec 21:1-10.
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