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Chemical Structure : CTA056
Catalog No.: PC-35182Not For Human Use, Lab Use Only.
CTA056 (CTA 056) is a potent, selective inhibitor of interleukin-2-inducible T-cell kinase (Itk) with IC50 of ~100 nM, also inhibits Btk (IC50=400 nM), but shows no significant inhibition for Etk (BMX kinase, IC50=5 uM).
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CTA056 (CTA 056) is a potent, selective inhibitor of interleukin-2-inducible T-cell kinase (Itk) with IC50 of ~100 nM, also inhibits Btk (IC50=400 nM), but shows no significant inhibition for Etk (BMX kinase, IC50=5 uM); CTA056 shows selectivity for Itk over other Tec family members; inhibits the phosphorylation of Itk and its effectors including PLC-γ, Akt, and ERK, as well as the decreased secretion of targeted genes such as IL-2 and IFN-γ in treated Jurkat and MOLT-4 cells; also exhibits apoptosis-inducing potential in Jurkat cells; demonstrates cytotoxic effect in xenograft models of T-cell leukemia and lymphoma.
| M.Wt | 554.698 | |
| Formula | C35H34N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Guo W, et al. Mol Pharmacol. 2012 Nov;82(5):938-47.
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