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Chemical Structure : CU-CPT17e
CAS No.: 2109805-75-4
Catalog No.: PC-20231Not For Human Use, Lab Use Only.
CU-CPT17e is a multi-TLR agonist withEC50 of 4.8 μM, 13.4 μM and 5.7 μM for strong NF-κB activation on hTLR 3, 8 and 9 respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $398 | In stock | |
| 10 mg | $588 | In stock | |
| 25 mg | $898 | In stock | |
| 100 mg | Get quote |
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CU-CPT17e is a multi-TLR agonist withEC50 of 4.8 μM, 13.4 μM and 5.7 μM for strong NF-κB activation on hTLR 3, 8 and 9 respectively.
CU-CPT17e shows negligible or no NF-κB activation via hTLR 2, 4, 5 and 7.
CU-CPT17e also exhibits significant cytotoxic activity, inhibiting the growth of cervical HeLa cancer cells (IC50 = 2.7 μM) by inducing apoptosis.
| M.Wt | 504.50 | |
| Formula | C27H24N2O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6,7-bis((4-nitrobenzyl)oxy)-2',3',5',6'-tetrahydrospiro[chromene-2,4'-pyran] |
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1. Zhang L, et al. J Med Chem. 2017;60:5029–5044.
2. Anindya Sarkar, et al. Med Chem Res. 2021 Jul;30(7):1377-1385.
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