CU-T12-9

Chemical Structure : CU-T12-9

CAS No.: 1821387-73-8

Catalog No.: PC-25127Not For Human Use, Lab Use Only.

CU-T12-9 is a specific TLR1/2 agonist with EC50 of 52.9 nM, directly targets TLR1/2 to initiate downstream signaling, induces TLR1/2 heterodimerization.

Packing	Price	Stock
5 mg	$88	In stock
10 mg	$128	In stock
25 mg	$218	In stock
50 mg		Get quote
100 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

Welcome credit card payment!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

CU-T12-9 is a specific TLR1/2 agonist with EC50 of 52.9 nM, directly targets TLR1/2 to initiate downstream signaling, induces TLR1/2 heterodimerization.
CU-T12-9 can strongly activate the SEAP signaling in HEK-Blue cells overexpressing hTLR2, but not in other TLR-overexpressing cells, including TLR3, TLR4, TLR5, TLR7, and TLR8.
CU-T12-9 selectively activates the TLR1/2 heterodimer, but not TLR2/6.
CU-T12-9 activates downstream signaling through TLR1/2 and NF-κB signaling pathway, CU-T12-9, at 5 μM, shows comparable activation to 66 nM (100 ng/ml) Pam3CSK4.
CU-T12-9 efficiently triggers NO production in Raw 264.7 cells and also in primary rat macrophage cells.
CU-T12-9 up-regulates the mRNA levels of TLR1, TLR2, TNF, IL-10, and iNOS.
CU-T12-9 not only selectively activates the TLR1/2 signaling pathway but also induces TLR1/2 heterodimerization.

Physicochemical Properties

M.Wt	362.31
Formula	C17H13F3N4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-methyl-4-nitro-2-(4-(4-(trifluoromethyl)phenyl)-1H-imidazol-1-yl)aniline

References

1. Cheng K, et al. Sci Adv. 2015;1(3):e1400139.

CU-T12-9

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.