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Chemical Structure : CU05-1189
Catalog No.: PC-21484Not For Human Use, Lab Use Only.
CU05-1189 is a non-peptide, allosteric inhibitor of the pleckstrin homology (PH) domain of PDK1, specifically inhibits Akt signaling pathway.
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CU05-1189 is a non-peptide, allosteric inhibitor of the pleckstrin homology (PH) domain of PDK1, specifically inhibits Akt signaling pathway.
CU05-1189 (2 uM) inhibits VEGF-induced proliferation of HUVECs, blocks VEGF-induced endothelial cell migration, invasion, and tube formation.
CU05-1189 inhibits the PDK1/Akt signaling pathway by suppressing membrane localization of PDK1.
CU05-1189 exerts antiangiogenic effects in matrigel plugs in the murine Matrigel plug assays.
CU05-1189 (50 mg/kg, oral) inhibits tumor angiogenesis and growth in an A549 xenograft mouse model.
| M.Wt | 405.45 | |
| Formula | C24H21F2N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jeongeun Park, et al. Front Pharmacol. 2023 Nov 16:14:1275749.
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