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CVT-10216

Chemical Structure : CVT-10216

CAS No.: 1005334-57-5

CVT-10216 (CVT 10216;GS455534;GS-455534)

Catalog No.: PC-61349Not For Human Use, Lab Use Only.

CVT-10216 (CVT10216) is a potent, highly selective, reversible inhibitor of ALDH2 with IC50 of 29 nM, shows no significant inhibition for ALDH1 (IC50=1,300 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CVT-10216 (CVT10216) is a potent, highly selective, reversible inhibitor of ALDH2 with IC50 of 29 nM, shows no significant inhibition for ALDH1 (IC50=1,300 nM).
CVT-10216 demonstrates therapeutic potential to reduce excessive drinking and to suppress relapse in abstinent alcoholics.
CVT-10216 also shows both anxiolytic and antidipsotropic properties in rats.
CVT-10216 selectively suppresses binge eating of palatable food and attenuates dopamine release in the accumbens of sugar-bingeing rats.

Physicochemical Properties

M.Wt 465.5
Formula C24H19NO7S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-[[[3-[4-[(Methylsulfonyl)amino]phenyl]-4-oxo-4H-1-benzopyran-7-yl]oxy]methyl]benzoic acid

References

1. Arolfo MP, et al. Alcohol Clin Exp Res. 2009 Nov;33(11):1935-44.

2. Overstreet DH, et al. Pharmacol Biochem Behav. 2009 Dec;94(2):255-61.

3. Bocarsly ME, et al. Behav Pharmacol. 2014 Apr;25(2):147-57.

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