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Chemical Structure : CVT-313
CAS No.: 199986-75-9
Catalog No.: PC-21886Not For Human Use, Lab Use Only.
CVT-313 (CVT313) is a potent, specific CDK2 inhibitor with IC50 of 0.5 uM (CDK2/cyclin A), equally inhibits CDK2/cyclin E.
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|---|---|---|---|
| 10 mg | $108 | In stock | |
| 25 mg | $178 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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CVT-313 (CVT313) is a potent, specific CDK2 inhibitor with IC50 of 0.5 uM (CDK2/cyclin A), equally inhibits CDK2/cyclin E.
CVT-313 displays 8.5-fold and 430-fold selectivity over CDK1 and CDK4, 2500-fold over mitogen-activated protein kinase and protein kinase A, and PKC.
CVT-313 inhibits cell proliferation at the G1/S or G2/M boundary (Caco-2 cell, IC50=4.5 uM).
CVT-313 inhibits Rb phosphorylation, inhibits neointima formation in rat carotid artery model of restenosis.
| M.Wt | 400.48 | |
| Formula | C20H28N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2{-bis-(hydroxyethyl)amino}-6-(4-methoxybenzyl-amino)-9-isopropyl-purine |
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1. Bhattacharjee RN, et al. Mol Cell Biol. 2001 Aug;21(16):5417-25.
2. Brooks EE, et al. J Biol Chem. 1997 Nov 14;272(46):29207-11.
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