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Chemical Structure : CVT-6694
Catalog No.: PC-22013Not For Human Use, Lab Use Only.
CVT-6694 (CVT6694) is a highly potent, selective A2B adenosine receptor antagonist with Ki of 7 nM (hA2B), >700-fold selective over human A1, A2A and A3 receptors.
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CVT-6694 (CVT6694) is a highly potent, selective A2B adenosine receptor antagonist with Ki of 7 nM (hA2B), >700-fold selective over human A1, A2A and A3 receptors.
CVT-6694 blocks the release of interleukin-6 and monocyte chemotactic protein-1 from bronchial smooth muscle cells (BSMC).
CVT-6694 inhibits the release of IL-6 and the differentiation of fibroblasts into myofibroblasts in human lung fibroblasts (HLFs).
| M.Wt | 452.86 | |
| Formula | C20H17ClN8O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rao V Kalla, et al. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1397-401.
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