Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : CW85319
Catalog No.: PC-21581Not For Human Use, Lab Use Only.
CW85319 is a small-molecule compound that enhances Axin2's interaction with GSK3β, shows a high-affinity binding with Axin2 with Kd of 5.8 uM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
CW85319 is a small-molecule compound that enhances Axin2's interaction with GSK3β, shows a high-affinity binding with Axin2 with Kd of 5.8 uM.
CW85319 effectively increased the binding interaction of Axin2 with GSK3β in a dose-dependent manner, increased the phosphorylation levels of Axin2 without altering its acetylation levels.
CW85319 triggers Axin2 ubiquitination and proteasomal degradation in colorectal cancer (CRC) cells.
CW85319 blocks Axin2-driven EMT programme and suppresses CRC cell motility behaviours.
CW85319 blocks Axin2-driven EM. CW85319 suppresses colorectal cancer cell proliferation by limiting Axin2-driven cell cycle progression.
| M.Wt | 411.52 | |
| Formula | C23H25NO4S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Li-Zhi Cheng, et al. Br J Pharmacol. 2023 Dec;180(23):3071-3091.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
