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Chemical Structure : CWHM-12
CAS No.: 1564286-55-0
Catalog No.: PC-45501Not For Human Use, Lab Use Only.
A novel active RGD peptidomimetic inhibitor of αv integrin with IC50s of 1.8/0.8/61/1.5/0.2 nM for αvβ1/αvβ3/αvβ5/αvβ6/αvβ8.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $400 | In stock | |
| 50 mg | $1200 | In stock | |
| 100 mg | $1680 | In stock |
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A novel active RGD peptidomimetic inhibitor of αv integrin with IC50s of 1.8/0.8/61/1.5/0.2 nM for αvβ1/αvβ3/αvβ5/αvβ6/αvβ8; no inhibition on αIIbβ3, α2β1 and α10β1 (>50 uM); significantly inhibits progression of pulmonary fibrosis in mice model.
Cystic Fibrosis
Preclinical
| M.Wt | 590.4662 | |
| Formula | C26H32BrN5O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 10.5 mg/mL |
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| Chemical Name/SMILES |
β-Alanine, N-[3-hydroxy-5-[(1,4,5,6-tetrahydro-5-hydroxy-2-pyrimidinyl)amino]benzoyl]glycyl-3-[3-bromo-5-(1,1-dimethylethyl)phenyl]-, (3S)- |
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1. Henderson NC, et al. Nat Med. 2013 Dec;19(12):1617-24.
2. Ulmasov B, et al. Cell Mol Gastroenterol Hepatol. 2016 Mar 16;2(4):499-518.
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