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Chemical Structure : CX4152
Catalog No.: PC-60624Not For Human Use, Lab Use Only.
CX4152 is a potent, selective CXCR2 inhibitor with IC50 of 7.6 nM, displays>1,000-fold selectivity over CXCR4 (IC50>50 uM).
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CX4152 is a potent, selective CXCR2 inhibitor with IC50 of 7.6 nM, displays>1,000-fold selectivity over CXCR4 (IC50>50 uM).
CX4152 inhibits CXCR2 signaling through downregulation of surface CXCR2.
CX4152 significantly inhibits CXCL8-mediated neutrophil migration and LPS-induced lung inflammation in mice.
CX4152 inhibits CXCR2/β-arrestin-2 association, cell migration and proliferation, and acute inflammation in mouse models.
| M.Wt | 435.538 | |
| Formula | C25H25NO4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ha H, et al. J Chem Inf Model. 2015 Aug 24;55(8):1720-38.
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