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Chemical Structure : CX797
Catalog No.: PC-60626Not For Human Use, Lab Use Only.
CX797 is a potent, specfic CXCR2 antagonist that inhibits IL8 down-regulation of forskolin-induced cAMP with IC50 of 7.79 uM.
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CX797 is a potent, specfic CXCR2 antagonist that inhibits IL8 down-regulation of forskolin-induced cAMP with IC50 of 7.79 uM.
CX797 inhibits IL8-mediated cAMP signaling and receptor degradation while specifically up-regulating IL8-mediated β-arrestin-2 recruitment.
CX797 also inhibits IL8-mediated cell migration.
| M.Wt | 382.5 | |
| Formula | C19H18N4OS2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ha H, et al. Mol Pharm. 2014 Jul 7;11(7):2431-41.
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