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Chemical Structure : CXCR2-IN-1
Catalog No.: PC-42300Not For Human Use, Lab Use Only.
A potent, CNS penetrant CXCR2 antagonist with pIC50 of 9.3.
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A potent, CNS penetrant CXCR2 antagonist with pIC50 of 9.3; shows neutrophil chemotaxis inhibition with pIC50 of 7.6; has developability profiles (CYP inhibition pIC<5.0, and hERG binding affinity pIC<4.0); exhibits favorable PK profile, reasonable CNS penetration, and good developability potential; orally bioavailable.
| M.Wt | 476.3492032 | |
| Formula | C19H20Cl2FN3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥5.4 mg/mL (Need ultrasonic and warming) |
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1. Xu H, et al. ACS Med Chem Lett. 2016 Feb 8;7(4):397-402.
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