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Chemical Structure : CXCR6 inhibitor 81
Catalog No.: PC-38129Not For Human Use, Lab Use Only.
CXCR6 inhibitor 81 is a potent (EC50=40 nM) and selective orally bioavailable small molecule antagonist of human CXCR6 receptor.
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CXCR6 inhibitor 81 is a potent (EC50=40 nM) and selective orally bioavailable small molecule antagonist of human CXCR6 receptor.
Compound 81 displays >10-fold improvement in potency in both the β-arrestin and cAMP assays (IC50 =40 and 540 nM, respectively) compared to ML339.
CXCR6 inhibitor 81 inhibits migration of SK-HEP-1 hepatoma cells in a dose dependent manner.
Compound 81 has promising oral DMPK data, significantly decreases tumor growth in a 30-day mouse xenograft model of HCC.
| M.Wt | 549.609 | |
| Formula | C27H30F3N3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Satyamaheshwar Peddibhotla, et al. Bioorg Med Chem Lett. 2020 Feb 15;30(4):126899.
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