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Chemical Structure : CXCR7 modulator 18
Catalog No.: PC-72636Not For Human Use, Lab Use Only.
CXCR7 modulator 18 is a novel potent, selective CXCR7 modulator with Ki of 13 nM, β-arrestin EC50 of 11 nM.
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CXCR7 modulator 18 is a novel potent, selective CXCR7 modulator with Ki of 13 nM, β-arrestin EC50 of 11 nM.
CXCR7 modulator 18 demonstrates excellent selectivity profile adrenergic α1a Kb >10 ,000 nM, and adrenergic β2 Kb, CXCR4 Ki >1 uM.
Administration of CXCR7 modulator 18 in mice led to a statistically significant increase in circulating concentrations of plasma stromal-cell-derived factor 1α (SDF-1α) of approximately 2-fold.
Chronic dosing of compound 18 in a mouse model of isoproterenol-induced cardiac injury further resulted in a statistically significant reduction of cardiac fibrosis.
| M.Wt | 522.694 | |
| Formula | C29H42N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Elnaz Menhaji-Klotz, et al. J. Med. Chem. 2018, 61, 8, 3685–3696
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