Chemical Structure : CZL-S092
CAS No.:
CZL-S092
Catalog No.: PC-24920Not For Human Use, Lab Use Only.
CZL-S092 is a potent, selective PLK4 inhibitor with IC50 of 0.9 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CZL-S092 is a potent, selective PLK4 inhibitor with IC50 of 0.9 nM.
CZL-S092 exhibitspotent antiproliferative activity against MCF-7, IMR-32 and SH-SY5Y cells with IC50 values of 2.828 μM, 1.143 μM, and 1.329 μM, respectively.
CZL-S092 exhibits excellent selectivity over other PLK family members (PLK1, PLK2, and PLK3).
CZL-S092 exhibits concentration-dependent inhibition of MCF-7 colony formation, inhibits growth of MCF-7 cancer cells at a concentration of 1.0 μM and almost completely inhibits at a concentration of 2.5 μM.
CZL-S092 (5 uM) effectively inhibited IMR-32 cell migration.
CZL-S092 displays good pharmacokinetic properties (Rats, F = 22.1 %).
Physicochemical Properties
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M.Wt
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418.49
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Formula
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C23H19FN4OS
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(E)-N-(3-fluorophenyl)-N-methyl-2-((3-(2-(pyridin-3-yl)vinyl)-1H-indazol-6-yl)thio)acetamide
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References
1. Liu N, et al. Eur J Med Chem. 2025 Jun 13;296:117867.
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