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Chemical Structure : CaCCinh-A01
CAS No.: 407587-33-1
Catalog No.: PC-20363Not For Human Use, Lab Use Only.
CaCCinh-A01 is a small molecule Ca(2+)-activated Cl(-) channel (CaCC) inhibitor, inhibits both I(sc) and transepithelial conductance in a concentration-dependent manner (IC50=6.3 uM).
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|---|---|---|---|
| 25 mg | $198 | In stock | |
| 100 mg | $498 | In stock | |
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CaCCinh-A01 is a small molecule Ca(2+)-activated Cl(-) channel (CaCC) inhibitor, inhibits both I(sc) and transepithelial conductance in a concentration-dependent manner (IC50=6.3 uM).
CaCCinh-A01 (30 μM) significantly reduced electrogenic K(+) secretion, detected as short-circuit current (I(sc)).
CaCCinh-A01 also inhibits TMEM16A channels (IC50=2.1μM, in TMEM16A-expressing FRT cells).
| M.Wt | 347.43 | |
| Formula | C18H21NO4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6-(tert-butyl)-2-(furan-2-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid |
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1. He Q, et al. Exp Physiol. 2011 Mar;96(3):305-16.
2. Ko EA, et al. Gut. 2014 Jul;63(7):1120-9.
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