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Chemical Structure : Cabozantinib (S-malate)
CAS No.: 1140909-48-3
Catalog No.: PC-42859Not For Human Use, Lab Use Only.
Cabozantinib (XL184) is a potent, multi-kinase inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50 of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $55 | In stock | |
| 100 mg | $135 | In stock | |
| 250 mg | $225 | In stock | |
| 1 g | Get quote |
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Cabozantinib (XL184) is a potent, multi-kinase inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50 of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively; eliminates tumor vasculature, reduces pericytes and empty basement membrane sleeves, causes widespread intratumoral hypoxia and tumor cell apoptosis, and slows regrowth of the tumor vasculature, also decreases invasiveness of primary tumors and reduces metastasis in pancreatic islet cancer; exerts marked anti-MPNST effects in vitro and in vivo.
Kidney Cancer
Approved
| M.Wt | 635.5931 | |
| Formula | C32H30FN3O10 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 23 mg/mL |
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| Chemical Name/SMILES |
Butanedioic acid, 2-hydroxy-, (2S)-, compd. with N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1) |
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1. You WK, et al. Cancer Res. 2011 Jul 15;71(14):4758-68.
2. Durante C, et al. Expert Opin Investig Drugs. 2011 Mar;20(3):407-413.
3. Torres KE, et al. Clin Cancer Res. 2011 Jun 15;17(12):3943-55.
4. Kurzrock R, et al. J Clin Oncol. 2011 Jul 1;29(19):2660-6.
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