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You are here:Home-Chemical Inhibitors & Agonists-GPCR-Calcium-sensing Receptor (CaSR)-Calhex-231
Calhex-231

Chemical Structure : Calhex-231

CAS No.: 652973-93-8

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Calhex-231 (Calhex231)

Catalog No.: PC-62905Not For Human Use, Lab Use Only.

Calhex-231 is a potent negative allosteric modulator of CaSR that blocks calcium-mediated activation with IC50 of 0.39 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Calhex-231 is a potent negative allosteric modulator of CaSR that blocks calcium-mediated activation with IC50 of 0.39 uM.
Calhex-231 inhibits myocyte hyperpolarization to the CaSR activator calindol and R-568.

Physicochemical Properties

M.Wt 406.954
Formula C25H27ClN2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-chloro-N-[(1S,2S)-2-[[(1R)-1-(1-naphthalenyl)ethyl]amino]cyclohexyl]-benzamide

References

1. Petrel C, et al. J Biol Chem. 2003 Dec 5;278(49):49487-94.

2. Weston AH, et al. Circ Res. 2005 Aug 19;97(4):391-8.

3. Kessler A, et al. J Med Chem. 2006 Aug 24;49(17):5119-28.

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