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Chemical Structure : Canagliflozin
CAS No.: 842133-18-0
Catalog No.: PC-42594Not For Human Use, Lab Use Only.
Canagliflozin (JNJ 28431754) is a highly potent and selective SGLT2 inhibitor with IC50 of 4.4, 3.7 and 2.0 nM for hSGLT2, rSGLT2 and mSGLT2, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $188 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $458 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Canagliflozin (JNJ 28431754) is a highly potent and selective SGLT2 inhibitor with IC50 of 4.4, 3.7 and 2.0 nM for hSGLT2, rSGLT2 and mSGLT2, respectively.
Canagliflozin (JNJ 28431754) displays >100-fold selectivity over SGLT1.
Canagliflozin (JNJ 28431754) improves glycemic control and beta-cell function in rodent models of T2DM, and reduces body weight gain in rodent models of obesity.
| M.Wt | 444.5157 | |
| Formula | C24H25FO5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
D-Glucitol, 1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-, (1S)- |
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1. Nomura S, et al. J Med Chem. 2010 Sep 9;53(17):6355-60.
2. Rosenstock J, et al. Diabetes Care. 2012 Jun;35(6):1232-8.
3. Liang Y, et al. PLoS One. 2012;7(2):e30555.
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