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Chemical Structure : Capmatinib
CAS No.: 1029712-80-8
Catalog No.: PC-43511Not For Human Use, Lab Use Only.
Capmatinib (INCB-28060, INC-280) is a highly potent, selective, ATP competitive inhibitor of c-MET kinase with IC50 of 0.13 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $88 | In stock | |
| 50 mg | $168 | In stock | |
| 100 mg | $288 | In stock | |
| 500 mg | $488 | In stock | |
| 1 g | Get quote |
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Capmatinib (INCB-28060, INC-280) is a highly potent, selective, ATP competitive inhibitor of c-MET kinase with IC50 of 0.13 nM.
Capmatinib (INCB-28060, INC-280) displays no activity against RONβ, EGFR and HER-3.
Capmatinib (INCB-28060, INC-280) inhibits c-MET phosphorylation (IC50=1 nM) in SNU-5 human gastric cancer cell line, is slightly more potent in H596 and H1437 lung cancer cell lines that express mutant c-MET due to an exon 14 deletion and a R988C mutation.
Capmatinib (INCB-28060, INC-280) inhibits c-MET phosphorylation and tumor growth in c-MET-driven mouse tumor models.
| M.Wt | ||
| Formula | C23H17FN6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 12.66 mg/mL |
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| Chemical Name/SMILES |
Benzamide, 2-fluoro-N-methyl-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]- |
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1. Liu X, et al. Clin Cancer Res. 2011 Nov 15;17(22):7127-38.
2. Brandes F, et al. BMC Cancer. 2015 Feb 19;15:71.
3. Moran-Jones K, et al. Sci Rep. 2015 Jul 3;5:11749.
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