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Carubicin

Chemical Structure : Carubicin

CAS No.: 39472-31-6

Carubicin (Carminomycin;Carminomycin I;Carminomicin I)

Catalog No.: PC-62441Not For Human Use, Lab Use Only.

Carubicin (Carminomycin) is an apoptosis inducer that targets the Golgi complex, induces apoptosis in CCRCC cells by a mechanism independent of p53 or HIF2, and induces cleavage of the Golgi protein p115 and the translocation of its C-terminal fragment to the nucleus.

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    Biological Activity

    Carubicin (Carminomycin) is an apoptosis inducer that targets the Golgi complex, induces apoptosis in CCRCC cells by a mechanism independent of p53 or HIF2, and induces cleavage of the Golgi protein p115 and the translocation of its C-terminal fragment to the nucleus.

    Physicochemical Properties

    M.Wt 513.499
    Formula C26H27NO10
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-4,6,9,11-tetrahydroxy-8,10-dihydro-7H-tetracene-5,12-dione

    References

    1. Woldemichael GM, et al. Cancer Res. 2011 Jan 1;71(1):134-42.

    2. Tevyashova AN, et al. J Antibiot (Tokyo). 2004 Feb;57(2):143-50.

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