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Cdk5i peptide

Chemical Structure : Cdk5i peptide

CAS No.:

Cdk5i peptide (ARAFGIPVRCYS)

Catalog No.: PC-20494Not For Human Use, Lab Use Only.

Cdk5i peptide is a Cdk5-derived 12-amino acid long Cdk5-derived peptide that interferes with the Cdk5/p25 complex with Kd of 0.17 uM, 40-fold more strongly to either Cdk5 or Cdk2 alone.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Cdk5i peptide is a Cdk5-derived 12-amino acid long Cdk5-derived peptide that interferes with the Cdk5/p25 complex with Kd of 0.17 uM, 40-fold more strongly to either Cdk5 or Cdk2 alone.
Cdk5i peptide ameliorates neurodegenerative phenotypes in cell and mouse models of Cdk5 hyperactivity.

Physicochemical Properties

M.Wt
Formula
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

References

1. Ping-Chieh Pao, et al. Proc Natl Acad Sci U S A. 2023 Apr 18;120(16):e2217864120.

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