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Chemical Structure : Cediranib
CAS No.: 288383-20-0
Catalog No.: PC-42450Not For Human Use, Lab Use Only.
Cediranib (AZD2171) is a highly potent, orally bioavailable, pan-VEGFR inibitor with IC50 of 1, 5, 3 nM for VEGFR1, 2, 3, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $158 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | $398 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Cediranib (AZD2171) is a highly potent, orally bioavailable, pan-VEGFR inibitor with IC50 of 1, 5, 3 nM for VEGFR1, 2, 3, respectively.
Cediranib (AZD2171) also inhibits c-Kit and PDGFRβ with IC50 of 2 and 5 nM, >36-fold selectivity over PDGFR-α, >1000-fold over Flt-3 and EGFR.
Cediranib (AZD2171) inhibits VEGF-stimulated proliferation and KDR phosphorylation with IC50 of 0.4 and 0.5 nM in human umbilical vein endothelial cells.
Cediranib (AZD2171) inhibits angiogenesis, neovascular survival and tumor growth in vivo.
| M.Wt | 450.5053 | |
| Formula | C25H27FN4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 49 mg/mL |
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| Chemical Name/SMILES |
Quinazoline, 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]- |
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1. Wedge SR, et al. Cancer Res. 2005 May 15;65(10):4389-400.
2. Denduluri N, et al. Clin Breast Cancer. 2005 Dec;6(5):460-3.
3. Batchelor TT, et al. Cancer Cell. 2007 Jan;11(1):83-95.
4. Cao C, et al. Cancer Res. 2006 Dec 1;66(23):11409-15.
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