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Chemical Structure : Cenicriviroc
CAS No.: 497223-25-3
Catalog No.: PC-38499Not For Human Use, Lab Use Only.
Cenicriviroc (TAK-652, TBR-652) is a potent, selective, orally active, dual CCR2/CCR5 antagonist with IC50 of 5.9/0.29 nM, inhibits both HIV-1 and HIV-2 and prevents viral cellular entry.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $188 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | Get quote | ||
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Cenicriviroc (TAK-652, TBR-652) is a potent, selective, orally active, dual CCR2/CCR5 antagonist with IC50 of 5.9/0.29 nM, inhibits both HIV-1 and HIV-2 and prevents viral cellular entry.
Cenicriviroc (TAK-652, TBR-652) exhibits effective EC50 of 0.03, 0.33, 0.45 and 0.98 nM against 4 R5 HIV-2 clinical isolates.
Cenicriviroc (≥20 mg/kg/day) significantly reduces monocyte/macrophage recruitment in vivo.
Cenicriviroc (TAK-652, TBR-652) shows antifibrotic effects, with significant reductions in collagen deposition, and collagen type 1 protein and mRNA expression across animal models of fibrosis.
| M.Wt | 696.94 | |
| Formula | C41H52N4O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(5E)-8-[4-(2-butoxyethoxy)phenyl]-1-(2-methylpropyl)-N-[4-[(S)-(3-propylimidazol-4-yl)methylsulfinyl]phenyl]-3,4-dihydro-2H-1-benzazocine-5-carboxamide |
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1. Lefebvre E, et al. PLoS One. 2016 Jun 27;11(6):e0158156
2. Kuwata T, et al. Antimicrob Agents Chemother. 2015 Nov 2;60(1):437-5
3. Baba M, et al. Antimicrob Agents Chemother. 2005 Nov;49(11):4584-91.
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