Centanafadine hydrochloride | Triple reuptake inhibitor

Chemical Structure : Centanafadine hydrochloride

Centanafadine hydrochloride (EB-1020 hydrochloride)

Catalog No.: PC-27839Not For Human Use, Lab Use Only.

Centanafadine hydrochloride (EB-1020 hydrochloride) is a potent triple reuptake inhibitor of reuptake transporters for norepinephrine (NET), dopamine (DAT) and serotonin (SERT) with IC50 of 6 nM, 38 nM and 83 nM respectively.

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Biological Activity

Centanafadine hydrochloride (EB-1020 hydrochloride) is a potent triple reuptake inhibitor of reuptake transporters for norepinephrine (NET), dopamine (DAT) and serotonin (SERT) with IC50 of 6 nM, 38 nM and 83 nM respectively.

Physicochemical Properties

M.Wt	245.75
Formula	C15H16ClN
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,5S)-1-(Naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride

References

1. Matuskey D, et al. J Psychopharmacol. 2023 Feb;37(2):164-171.

2. Bymaster FP, et al. Synapse 66: 522–532.

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Centanafadine hydrochloride (EB-1020 hydrochloride)

Biological Activity

Physicochemical Properties

References

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