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Chemical Structure : Centrinone
CAS No.: 1798871-30-3
Catalog No.: PC-45523Not For Human Use, Lab Use Only.
Centrinone (LCR-263) is a selective, reversible PLK4 inhibitor with Ki of 0.16 nM in vitro.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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Centrinone (LCR-263) is a selective, reversible PLK4 inhibitor with Ki of 0.16 nM in vitro.
Centrinone (LCR-263) causes centrosome depletion at 100 nM in human and other vertebrate cells.
Centrinone (LCR-263) shows >1000-fold selectivity over Aurora A and Aurara B; leads to irreversible, p53-dependent G1 arrest by an unknown mechanism.
| M.Wt | 633.6468 | |
| Formula | C26H25F2N7O6S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31 mg/mL |
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| Chemical Name/SMILES |
4-Pyrimidinamine, 2-[[2-fluoro-4-[[(2-fluoro-3-nitrophenyl)methyl]sulfonyl]phenyl]thio]-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-(4-morpholinyl)- |
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1. Wong YL, et al. Science. 2015 Jun 5;348(6239):1155-60.
2. Meitinger F, et al. J Cell Biol. 2016 Jul 18;214(2):155-66.
3. Guizzunti G, et al. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6590-E6599.
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