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Chemical Structure : Cevidoplenib dimesylate
CAS No.: 2043659-93-2
Catalog No.: PC-22084Not For Human Use, Lab Use Only.
Cevidoplenib dimesylate (SKI-O-703) is a potent, selective, orally active spleen tyrosine kinase (Syk) inhibitor with IC50 of 6.2 nM.
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| 10 mg | $528 | In stock | |
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Cevidoplenib dimesylate (SKI-O-703) is a potent, selective, orally active spleen tyrosine kinase (Syk) inhibitor with IC50 of 6.2 nM.
SKI-O-703 is the orally bioavailable dimesylate salt form of Cevidoplenib (SKI-O-592, Cat#PC-61366).
SKI-O-592 is approximately 9-fold more potent than R406 as a Syk kinase inhibitor.
SKI-O-592 is highly specific for Syk, displays 67- to 2753-fold selectivity against a panel of kinases.
SKI-O-703 significantly ameliorated synovitis, with fewer neutrophils and macrophages infiltrated into the synovial tissue, in model of serum-transferred arthritis.
SKI-O-703 attenuates the progression of autoantibody-mediated autoimmune diseases by inhibiting both autoantibody-producing and autoantibody-sensing cells.
| M.Wt | 665.74 | |
| Formula | C27H35N7O9S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Methanone, cyclopropyl[5-[[4-[4-[[(4S)-4-hydroxy-2-isoxazolidinyl]methyl]-3-methyl-1H-pyrazol-1-yl]-2-pyrimidinyl]amino]-1-methyl-1H-indol-3-yl]-, methanesulfonate (1:2) |
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1. Cho S, et al. Clin Exp Immunol. 2023 Mar 8;211(1):31-45.
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