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Chemical Structure : Chalcone 4 hydrate
CAS No.: 1202866-96-3
Catalog No.: PC-60261Not For Human Use, Lab Use Only.
Chalcone 4 hydrate is a potent, selective inhibitor of CXCL12 binding to CXCR4 and CXCR7 with IC50 of 200 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $228 | In stock | |
| 25 mg | $388 | In stock | |
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| 100 mg | Get quote |
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Chalcone 4 hydrate is a potent, selective inhibitor of CXCL12 binding to CXCR4 and CXCR7 with IC50 of 200 nM.
Chalcone 4 hydrate shows no activities for CCL5 and CXCL8 chemokines; inhibits calcium responses mediated by CXCR4 and prevents CXCR4 internalization.
Chalcone 4 hydrate blocks chemotaxis of human peripheral blood lymphocytes ex vivo, shows activity in vivo in mouse model of allergic eosinophilic airway inflammation.
| M.Wt | 306.74 | |
| Formula | C16H15ClO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(E)-1-(4-Chlorophenyl)-3-(4-hydroxy-3-methoxyphenyl)-2-propen-1-one hydrate |
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1. Gasparik V, et al. ACS Med Chem Lett. 2011 Dec 9;3(1):10-4.
2. Hachet-Haas M, et al. J Biol Chem. 2008 Aug 22;283(34):23189-99.
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