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Chemical Structure : Chromeceptin
Catalog No.: PC-61655Not For Human Use, Lab Use Only.
A cell-permeable benzochromene that selectively impairs the viability and growth of IGF2-overexpressing hepatocellular carcinoma cells, binds to MFP-2, stimulates the expression of IGFBP-1 and SOCS-3 through activation of STAT6.
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A cell-permeable benzochromene that selectively impairs the viability and growth of IGF2-overexpressing hepatocellular carcinoma cells, binds to MFP-2, stimulates the expression of IGFBP-1 and SOCS-3 through activation of STAT6; blocks insulin-induced adipogenesis in 3T3-L1 cells (100% blockage at <20 ng/uL) and selectively suppresses IGF2-dependent growth of HepG2 carcinoma cells (IC50=29 nM); a potent IGF2 signaling inhibitor.
| M.Wt | 359.35 | |
| Formula | C19H16F3N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Choi Y, et al. Chem Biol. 2006 Mar;13(3):241-9.
2. Jung D, et al. Biochem J. 2012 Dec 15;448(3):409-16.
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