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Chemical Structure : Cilomilast
CAS No.: 153259-65-5
Catalog No.: PC-42698Not For Human Use, Lab Use Only.
Cilomilast (SB207499) is a potent and selective PDE4 inhibitor with IC50 of 95/120 nM for LPDE4/HPDE4.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $368 | In stock | |
| 100 mg | Get quote |
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Cilomilast (SB207499) is a potent and selective PDE4 inhibitor with IC50 of 95/120 nM for LPDE4/HPDE4.
Cilomilast (SB207499) shows selectivity for PDE4 over the other PDE isozymes and is 75-fold more selective than (R)-rolipram with respect to LPDE4 activity versus HPDE4 activity.
Cilomilast (SB207499) inhibits antigen-induced bronchoconstriction in conscious guinea pigs at 30 mg/kg and orally acitive.
| M.Wt | 343.4168 | |
| Formula | C20H25NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Cyclohexanecarboxylic acid, 4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, cis- |
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1. Christensen SB, et al. J Med Chem. 1998 Mar 12;41(6):821-35.
2. Barnette MS, et al. J Pharmacol Exp Ther. 1998 Jan;284(1):420-6.
3. Griswold DE, et al. J Pharmacol Exp Ther. 1998 Nov;287(2):705-11.
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