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Cirsiliol

Chemical Structure : Cirsiliol

CAS No.: 34334-69-5

Cirsiliol

Catalog No.: PC-27992Not For Human Use, Lab Use Only.

Cirsiliol is a selective 5-lipoxygenase (5-LO) inhibitor with IC50 of 0.1 uM for 5-LO purified from rat basophilic leukemia cells, also binds and inhibits TYK2, inhibits ESCC growth in vitro and in vivo, also induces autophagy and mitochondrial apoptosis in osteosarcoma.

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25 mg $218 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Cirsiliol is a selective 5-lipoxygenase (5-LO) inhibitor with IC50 of 0.1 uM for 5-LO purified from rat basophilic leukemia cells, also binds and inhibits TYK2, inhibits ESCC growth in vitro and in vivo, also induces autophagy and mitochondrial apoptosis in osteosarcoma.

Physicochemical Properties

M.Wt 330.29
Formula C17H14O7
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(3,4-dihydroxyphenyl)-5-hydroxy-6,7-dimethoxy-4H-chromen-4-one

References

1. Kohno SW, et al. Adv Prostaglandin Thromboxane Leukot Res. 1985;15:217-9.

2. Yoshimoto T, et al. Biochem Biophys Res Commun. 1983 Oct 31;116(2):612-8.

3. Horie T, et al. J Med Chem. 1986 Nov;29(11):2256-62.

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