Chemical Structure : Cladoniamide A
CAS No.:
1041751-96-5
Cladoniamide A
Catalog No.: PC-27037Not For Human Use, Lab Use Only.
Cladoniamide A is a reversible broad-spectrum antiviral targets the human V-ATPase VO domain, interferes with V-ATPase-dependent acidification of the host endolysosomal network thus preventing viral entry.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Cladoniamide A is a reversible broad-spectrum antiviral targets the human V-ATPase VO domain, interferes with V-ATPase-dependent acidification of the host endolysosomal network thus preventing viral entry.
Cladoniamide A shows single-digit nanomolar antiviral activity and a high selectivity index (SI: 10 3 -10 4 ) against human enveloped viruses [e.g., SARS-CoV-2 variants, influenza A viruses (H1N1, H5N1), respiratory syncytial virus, dengue serotypes 1-4, and Zika virus].
Cladoniamide A inhibits the V-ATPase rotary motor by occupying unique binding sites in the membrane-embedded V o motor.
Physicochemical Properties
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M.Wt
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437.84
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Formula
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C22H16ClN3O5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(5aR,8aS)-10-chloro-5a,8a-dihydroxy-14-methoxy-7-methyl-8a,13-dihydropyrrolo[3',4':5,6]pyrido[1,2-a:3,4-b']diindole-6,8(5aH,7H)-dione
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References
1. Pérez-Vargas J, et al. Res Sq [Preprint]. 2026 Jun 3:rs.3.rs-9889115.
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