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Chemical Structure : Clemizole
Catalog No.: PC-45789Not For Human Use, Lab Use Only.
An H1 histamine receptor antagonist that substantially inhibits HCV replication by suppression of NS4B's RNA binding (IC50=24 nM) with little toxicity for the host cells.
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Clemizole is an H1 histamine receptor antagonist that substantially inhibits HCV replication by suppression of NS4B's RNA binding (IC50=24 nM) with little toxicity for the host cells.
Clemizole also selectively and efficiently blocks TRPC5 currents and Ca(2+) entry with IC50 of 1-1.3 uM, 6-fold selectivity over TRPC4β (IC50 = 6.4 µM), and almost 10-fold selectivity over TRPC3 (IC50 =9.1 uM) and TRPC6 (IC50=11.3 uM), only very weakly affects TRPM3, TRPM8 and TRPV1, V2, V3, and V4 channels.
| M.Wt | 325.8352 | |
| Formula | C19H20ClN3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Richter JM, et al. Mol Pharmacol. 2014 Nov;86(5):514-21.
2. Einav S, et al. Nat Biotechnol. 2008 Sep;26(9):1019-27.
3. Einav S, et al. J Infect Dis. 2010 Jul 1;202(1):65-74.
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