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Chemical Structure : Clitocine
Catalog No.: PC-60461Not For Human Use, Lab Use Only.
A naturally occurring nucleoside analog that possesses antitumor activity, also is a potent and efficacious readthrough agent.
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A naturally occurring nucleoside analog that possesses antitumor activity, also is a potent and efficacious readthrough agent; weakly inhibits adenosine kinase (Ki=3 uM), and inhibits L1210 cells in vitro with LD50 of 30 nM; potently inhibits Mcl-1, effectively induces drug-resistant human cancer cell apoptosis in vitro and inhibits tumor xenograft growth in vivo; a potent and efficacious suppressor of nonsense mutations.
| M.Wt | 287.232 | |
| Formula | C9H13N5O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Moss RJ, et al. J Med Chem. 1988 Apr;31(4):786-90.
2. Lee CH, et al. Bioorg Med Chem Lett. 2001 Sep 17;11(18):2419-22.
3. Sun JG, et al. Apoptosis. 2014 May;19(5):871-82.
4. Friesen WJ, et al. RNA. 2017 Apr;23(4):567-577.
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