Chemical Structure : Clonixeril
CAS No.:
21829-22-1
Clonixeril
(NSC 335504, CXL)
Catalog No.: PC-24871Not For Human Use, Lab Use Only.
Clonixeril (CXL) is a highly potent, non-nucleotide hSTING modulator, has two modes of interaction with hSTING, shows weak agonist activity at micromolar concentrations, acts as a hSTING antagonist at <1 nM (EC50 < 1fM).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Clonixeril (CXL) is a highly potent, non-nucleotide hSTING modulator, has two modes of interaction with hSTING, shows weak agonist activity at micromolar concentrations, acts as a hSTING antagonist at <1 nM (EC50 < 1fM).
Clonixeril displays this exceptionally strong inhibitory effect on hSTING mediated IFN-1 production using a THP-1 cell luciferase reporter for interferon regulatory factor 3 (IRF3).
Clonixeril is a potent inhibitor of hSTING, with activity even at attomolar (10-18 M) concentrations
Clonixeril reduces hSTING oligomerization at concentrations down to attomolar levels with an inverse dose response.
Clonixeril binds to hSTING CTD with SPR KD of 430 nM.
Physicochemical Properties
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M.Wt
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336.77
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Formula
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C16H17ClN2O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-Pyridinecarboxylic acid, 2-[(3-chloro-2-methylphenyl)amino]-, 2,3-dihydroxypropyl ester
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References
1. Sparks RP, et al. ACS Cent Sci. 2025 Jun 6;11(6):994-1008.
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