ClpP inhibitor M21 |CAS:1151944-58-9 Probechem Biochemicals

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Chemical Structure : ClpP inhibitor M21

ClpP inhibitor M21

Catalog No.: PC-35421Not For Human Use, Lab Use Only.

ClpP inhibitor M21 is a noncompetitive inhibitor of ClpP with IC50 of 41.42 uM, inhibits ClpP cleavage of SUc-LY-AMC substrate in a peptidase assay.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ClpP inhibitor M21 is a noncompetitive inhibitor of ClpP with IC50 of 41.42 uM, inhibits ClpP cleavage of SUc-LY-AMC substrate in a peptidase assay.
ClpP inhibitor M21 alters α-toxin expression in a ClpP-dependent manner and attenuate S. aureus virulence via ClpP inhibition.
ClpP inhibitor M21 blocks the pathogenicity of infection in animal models.

Physicochemical Properties

M.Wt	385.452
Formula	C19H15NO4S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-2-(5-(4-(benzyloxy)benzylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid

References

1. Gao P, et al. Proc Natl Acad Sci U S A. 2018 Jul 16. pii: 201720520.

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