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Chemical Structure : Cobicistat
CAS No.: 1004316-88-4
Catalog No.: PC-42617Not For Human Use, Lab Use Only.
Cobicistat (GS-9350) is a pharmacoenhancer that acts as potent and selective inhibitor of human CYP3A with IC50 of 30-285 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $172 | In stock | |
| 50 mg | $600 | In stock | |
| 100 mg | $1000 | In stock |
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Cobicistat (GS-9350) is a pharmacoenhancer that acts as potent and selective inhibitor of human CYP3A with IC50 of 30-285 nM.
Cobicistat (GS-9350) is a more selective than RTV with much reduced inhibitory activity toward CYP2D6, CYP2C8, and CYP2C9.
| M.Wt | 776.0227 | |
| Formula | C40H53N7O5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 29 mg/mL |
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| Chemical Name/SMILES |
2,7,10,12-Tetraazatridecanoic acid, 12-methyl-13-[2-(1-methylethyl)-4-thiazolyl]-9-[2-(4-morpholinyl)ethyl]-8,11-dioxo-3,6-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (3R,6R,9S)- |
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1. Xu L, et al. ACS Med Chem Lett. 2010 May 17;1(5):209-13.
2. Lepist EI, et al. Antimicrob Agents Chemother. 2012 Oct;56(10):5409-13.
3. Stray KM, et al. Antimicrob Agents Chemother. 2013 Oct;57(10):4982-9.
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