Chemical Structure : Collismycin A
CAS No.:
158792-24-6
Collismycin A
(SF2738A, CMA)
Catalog No.: PC-24827Not For Human Use, Lab Use Only.
Collismycin A (CMA, SF2738A) is a microbial product produced by Streptomyces sp. with anti-proliferative activity against cancer cells, acts as a specific iron chelator and binds both Fe(II) and Fe(III) ions and forms a 2:1 chelator-iron complex with a redox-inactive center.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Collismycin A (CMA, SF2738A) a microbial product produced by Streptomyces sp. with anti-proliferative activity against cancer cells, acts as a specific iron chelator and binds both Fe(II) and Fe(III) ions and forms a 2:1 chelator-iron complex with a redox-inactive center.
Collismycin A does not bind to other metal ions such as Zn(II), Mn(II), Cu(II), and Mg(II).
Collismycin A exhibits cell growth inhibition in various cancer cell lines (HeLa, IC50=0.3 uM).
Collismycin A induces cell cycle arrest at the G1 phase with a marked decrease of cyclin D1, affects the glycolytic pathway due to the accumulation of HIF-1α.
Collismycin A is active against a variety of bacteria (MICs=6.25 and 100 μg/mL) and fungi (MICs=12.5-100 μg/mL).
Physicochemical Properties
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M.Wt
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275.33
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Formula
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C13H13N3O2S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(E)-4-Methoxy-5-(methylthio)-[2,2'-bipyridine]-6-carbaldehydeoxime
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References
1. Gomi, et al. J. Antibiot. (Tokyo) 47(12), 1385-1394 (1994).
2. Kawatani M, et al. Sci Rep. 2016 Dec 6:6:38385.
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