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Columbianadin

Chemical Structure : Columbianadin

CAS No.: 5058-13-9

Columbianadin

Catalog No.: PC-28715Not For Human Use, Lab Use Only.

Columbianadin is a coumarin from heracleum brunonis with anti-inflammatory, analgesic, thrombogenesis-inhibiting and anti-tumor effects. inhibits the PI3K/Akt signaling pathway in GBM cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Columbianadin is a coumarin from heracleum brunonis with anti-inflammatory, analgesic, thrombogenesis-inhibiting and anti-tumor effects. inhibits the PI3K/Akt signaling pathway in GBM cells.
Columbianadin inhibits depolarization induced Ca2+ uptake in rat pituitary GH3 cells.
CBN inhibits the growth and proliferation of GBM cells in a dose-dependent manner.
Columbianadin arrested the cell cycle in G0/G1 phase and induced the apoptosis of GBM cells.
Columbianadin inhibited GBM growth in an orthotopic mouse model of GBM through inhibiting PI3K/Akt signaling pathway.
Columbianadin inhibited both mechanical and cold hypersensitivity induced by oxaliplatin.

Physicochemical Properties

M.Wt 328.36
Formula C19H20O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-2-(2-Oxo-8,9-dihydro-2H-furo[2,3-h]chromen-8-yl)propan-2-yl (Z)-2-methylbut-2-enoate

References

1. Törnquist K, et al. Planta Med. 1990 Feb;56(1):127-9.

2. Zhang W, et al. Biochem Pharmacol. 2024 May;223:116112.

3. Su X, et al. Front Pharmacol. 2020 Jan 9;10:1522.

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