Chemical Structure : Columbianadin
CAS No.: 5058-13-9
Catalog No.: PC-28715Not For Human Use, Lab Use Only.
Columbianadin is a coumarin from heracleum brunonis with anti-inflammatory, analgesic, thrombogenesis-inhibiting and anti-tumor effects. inhibits the PI3K/Akt signaling pathway in GBM cells.
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|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
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Columbianadin is a coumarin from heracleum brunonis with anti-inflammatory, analgesic, thrombogenesis-inhibiting and anti-tumor effects. inhibits the PI3K/Akt signaling pathway in GBM cells.
Columbianadin inhibits depolarization induced Ca2+ uptake in rat pituitary GH3 cells.
CBN inhibits the growth and proliferation of GBM cells in a dose-dependent manner.
Columbianadin arrested the cell cycle in G0/G1 phase and induced the apoptosis of GBM cells.
Columbianadin inhibited GBM growth in an orthotopic mouse model of GBM through inhibiting PI3K/Akt signaling pathway.
Columbianadin inhibited both mechanical and cold hypersensitivity induced by oxaliplatin.
| M.Wt | 328.36 | |
| Formula | C19H20O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-2-(2-Oxo-8,9-dihydro-2H-furo[2,3-h]chromen-8-yl)propan-2-yl (Z)-2-methylbut-2-enoate |
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1. Törnquist K, et al. Planta Med. 1990 Feb;56(1):127-9.
2. Zhang W, et al. Biochem Pharmacol. 2024 May;223:116112.
3. Su X, et al. Front Pharmacol. 2020 Jan 9;10:1522.

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