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Chemical Structure : Compound 2B5
Catalog No.: PC-20594Not For Human Use, Lab Use Only.
Compound 2B5 is a potent small molecule against S. mutans with IC50 of 1.9 uM, specifically targets the key response regulator VicR (Kd=87 uM) in both S. mutans and S. aureus.
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Compound 2B5 is a potent small molecule against S. mutans with IC50 of 1.9 uM, specifically targets the key response regulator VicR (Kd=87 uM) in both S. mutans and S. aureus.
Compound 2B5 exhibits potent antibiofilm activity against S. aureus with IC50 of 3.5 uM.
Compound 2B5 inhibits expression of vicR and VicR-regulated genes, reduces biofilm formation.
Compound 2B5 (100 uM) inhibits S. mutans-induced virulence in a rat model of dental caries, does not significantly affect bacterial colonization.
| M.Wt | 392.63 | |
| Formula | C23H44N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Liu C, et al. mBio. 2023 Apr 19:e0013723.
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