Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Compound 3235-0367
Catalog No.: PC-49502Not For Human Use, Lab Use Only.
Compounmd 3235-0367 is a small-molecule inhibitor of FZD8 with IC50 of 7.1 uM against mouse FZD8 cysteine-rich domain (CRD) by cell-based assays and KD of 2.5 uM inb BLI assays, inhibits Wnt3a-induced β-catenin signaling.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Compounmd 3235-0367 is a small-molecule inhibitor of FZD8 with IC50 of 7.1 uM against mouse FZD8 cysteine-rich domain (CRD) by cell-based assays and KD of 2.5 uM inb BLI assays, inhibits Wnt3a-induced β-catenin signaling.
Compounmd 3235-0367 inhibits Wnt induced LRP6 phosphorylation in HEK293T cells.
Treatment of CCD-18Co fibroblasts and patient-derived myofibroblasts with the FZD8 inhibitor 3235-0367 reduced extracellular matrix (ECM) expression.
| M.Wt | 518.57 | |
| Formula | C28H30N4O6 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Ho-Jin Lee, et al. J Biol Chem. 2015 Dec 18;290(51):30596-606.
2. Amy Lewis, et al. Clin Sci (Lond). 2022 Oct 14;136(19):1405-1423.
3. Ahadome SD, et al. Exp Cell Res. 2017 Aug 1;357(1):116-123.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
