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Chemical Structure : Compound 5-6
Catalog No.: PC-21120Not For Human Use, Lab Use Only.
Compound 5-6 (FtsW inhibitor 5-6) is a specific small molecule inhibitor of bacterial cell wall polymerase FtsW, competes with Lipid II for binding to FtsW with Ki of 0.8 uM, has an MIC of 1 μg /mL against S. aureus.
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Compound 5-6 (FtsW inhibitor 5-6) is a specific small molecule inhibitor of bacterial cell wall polymerase FtsW, competes with Lipid II for binding to FtsW with Ki of 0.8 uM, has an MIC of 1 μg /mL against S. aureus.
FtsW inhibitor 5-6 is selective for inhibition of FtsWI over two other S. aureus enzymes that belong to the other class of peptidoglycan polymerases.
FtsW inhibitor 5-6 competes with Lipid II for binding to S. aureus FtsWI with Ki of 0.8 uM in competitive binding assay.
FtsW inhibitor 5-6 prevents Lipid II from binding to the donor site of FtsW.
| M.Wt | 415.45 | |
| Formula | C23H21N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Youngseon Park, et al. Angew Chem Int Ed Engl. 2023 Jun 19;62(25):e202301522.
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