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Compound 621433144

Chemical Structure : Compound 621433144

CAS No.: 2223169-38-6

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Compound 621433144 (ZINC000621433144, Z3269026405)

Catalog No.: PC-36061Not For Human Use, Lab Use Only.

Compound 621433144 (ZINC000621433144, Z3269026405) is a potent, selective full agonist of the D4 receptor with 2,500-fold subtype selectivity.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Compound 621433144 (ZINC000621433144, Z3269026405) is a potent, selective full agonist of dopamine D4 receptor (DRD4) with 2,500-fold subtype selectivity.
    Compound 621433144 was also functionally selective, with a 17-fold bias towards Gi signalling versus β-arrestin recruitment, compared to the characteristic agonist quinpirole.

    Physicochemical Properties

    M.Wt 301.434
    Formula C18H27N3O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-N-((3R,4S)-1-isopropyl-4-methylpyrrolidin-3-yl)-1-methylisoindoline-2-carboxamide

    References

    1. Lyu J, et al. Nature. 2019 Feb 6. doi: 10.1038/s41586-019-0917-9.

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