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Chemical Structure : Compstatin
CAS No.: 206645-99-0
Catalog No.: PC-21941Not For Human Use, Lab Use Only.
Compstatin is a 13-residue cyclic peptide inhibitor of complement C3, specifically binds to C3 and inhibits complement activation by blocking C3 convertase-mediated cleavage of C3.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $388 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Compstatin is a 13-residue cyclic peptide inhibitor of complement C3, specifically binds to C3 and inhibits complement activation by blocking C3 convertase-mediated cleavage of C3.
Compstatin effectively inhibits the generation of C3a and sC5b-9 and the binding of C3/ C3 fragments to the polymer surface.
Compstatin prolongs survival of ex vivo perfused pig xenografts.
| M.Wt | 1550.78 | |
| Formula | C66H99N23O17S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-((4R,7S,10S,13S,19S,22S,25S,28S,31S,34R)-10,13-Bis((1H-imidazol-4-yl)methyl)-19-((1H-indol-3-yl)methyl)-4-(((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)carbamoyl)-34-((2S,3S)-2-amino-3-methylpentanamido)-25-(3-amino-3-oxopropyl)-7-(3-guanidinopropyl)-28,31-diisopropyl-6,9,12,15,18,21,24,27,30,33-decaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32-decaazacyclopentatriacontan-22-yl)acetic acid |
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1. Morikis D, et al. Protein Sci. 1998 Mar;7(3):619-27.
2. Nilsson B, et al. Blood. 1998 Sep 1;92(5):1661-7.
3. Fiane AE, et al. Xenotransplantation. 1999 Feb;6(1):52-65.
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